abstract |
A new peptide which accelerates the activation of Protein C by thrombin, has an 118 aminoacid chain (structure given) with optional N and C terminal additions (also of defined structure). Also claimed are DNA sequences coding for the peptide. Prepn. of the peptide is by expression of a plasmid contg. a DNA sequence coding for the peptide (e.g. pSV2TMD1, pSV2TMD5) in a transformant organism such as E.coli K-12, Saccharomyces cerevisiae, HeLa cells, or Chinese hamster ovary. |