| abstract |
The invention provides compounds of formula (I):n wherein R² is phenyl optionally substituted by one or more substituents each independently selected from nitro, halo, C₁-C₄ alkyl, C₁-C₄ alkoxy, fluoro-(C₁-C₄)alkoxy, aryl-(C₁-C₄ alkoxy), C₁-C₄ alkylthio, C₁-C₄ alkylsulphonyl, hydroxy, trifluoromethyl and cyano; nR¹ is C₁-C₆ alkyl or aryl-(C₁-C₄)alkyl; nY is an alkylene group of from 2 to 8 carbon atoms which may be straight or branched-chain having at least 2 carbon atoms in the chain linking X to the oxygen atom; nX is 1-imidazolyl optionally substituted with from 1 to 3 substituents which may be C₁-C₄ alkyl groups or halogen atoms, or wherein the 3 and 4 positions may be linked by -(CH₂) p - where p is 3 or 4; or 1- or 2-benzimidazolyl optionally substituted with one or more substituents each selected from C₁-C₄ alkyl, C₁-C₄ alkoxy, halo, CF₃ and CN; nand Z completes a 5 or 6 membered carbocyclic or heterocyclic ring having a carbonyl group attached to the 5-position of the dihydropyridine ring; wherein "aryl" means phenyl optionally substituted by one or more substituents each independently selected from halo, trifluoromethyl, C₁-C₄ alkyl, hydroxy, C₁-C₄ alkoxy, (C₁-C₄ alkoxy)carbonyl, sulphamoyl and cyano. |