http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0222598-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d269c8e41f178194d858c230c9f85e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-00 |
| filingDate | 1986-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cb29dda9e0948e298a73fc902d8e8e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f9787051ca7b339343d3f22659d306f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bed404dde9a3ccbc6fc5de488a934e2b |
| publicationDate | 1987-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0222598-A2 |
| titleOfInvention | Dihydropyridine anti-ischaemic and antihypertensive agents |
| abstract | 1,4-Dihydropyridine anti-ischaemic and antihypertensive agent of the formula:-n or a pharmaceutically acceptable salt thereof, nwherein R is selected from (a) phenyl optionally substituted by 1 or 2 substituents each independently selected from nitro, halo, C₁-C₄ alkyl, C₁-C₄ alkoxy, hydroxy, trifluoromethyl and cyano (b) 1- and 2- naphthyl and (c) benzofuranyl; benzothienyl; pyridyl optionally substituted by methyl, methylthio, cyano or halo; quinolyl; benzoxazolyl; benzothiazolyl; furyl; pyrimidinyl; thiazolyl; 2,1,3-benzoxadiazol-4-yl; 2,1,3-benzothiadiazol-4-yl; and thienyl optionally monosubstituted by halo or C₁-C₄ alkyl; nR¹ and R² are each independently C₁-C₄ alkyl; nX is O or S(O) p where p is 0, 1 or 2; nR³ is H or C₁-C₄ alkyl; nand R⁴ is selected from:-n (i) Het¹ and -CH₂Het¹ where Het¹ is a triazolyl, imidazolyl, imidazolinyl, pyrimidinyl or a partially saturated derivative thereof, pyridyl, furyl, thienyl, oxadiazolyl, thiadiazolyl, triazinyl, thiazolyl, thiazolinyl, -pyrazinyl, pyrrolinyl, tetrazolyl, benzothiazolyl, quinoxalinyl, quinazolinyl or purinyl group, Het¹ being attached to the adjacent carbon atom either by a ring carbon or a ring nitrogen atom, and being optionally substituted by 1 to 3 substituents each selected from C₁-C₄ alkyl, C₁-C₄ alkoxy, halo, hydroxy, oxo, cyano, -(CH₂) n COOH, -(CH₂) n COO(C₁-C₄ alkyl), -(CH₂) n CONR⁵R⁶, -NR⁵R⁶ and -SO₂NR⁵R⁶ where n is 0 or 1 and either R⁵ and R⁶ are each independently H or C₁-C₄ alkyl, or R⁵ and R⁶ taken together with the nitrogen atom to which they are attached represent a pyrrolidinyl, piperidino, morpholino, 4-methyl- piperazin-1-yl or 4-formylpiperazin-1-yl group; (ii) -CH₂OHet², -CH₂SHet², and -CH₂NHHet² where Het² is a group as defined for Het¹ above with the proviso that Het² is attached to the adjacent hetero atom by a ring carbon atom; (iii) -CH₂N₃; (iv) -CH₂NR⁵R⁶ where R⁵ and R⁶ are as defined above; (v) -CH₂-O-(C₁-C₄ alkyl); and (vi) -(CH₂) m -OH where m is 1 or 2, with the proviso that when m is 2, R³ is H. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0232025-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4971984-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0299727-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0232025-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0271059-A1 |
| priorityDate | 1985-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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