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filingDate 1988-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1988-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0291055-A2
titleOfInvention Stable creatinamidinohydrolase mutants
abstract A new creatinamidinohydrolase, in which alanine at position 109 of the amino acid sequence of the wild-type enzyme is replaced by valine and optionally one or more additional amino acids of the wild-type enzyme are mutated, is more stable than the wild-type enzyme and is therefore more suitable for reagents. For their production, recombinant DNA is expressed according to known genetic engineering methods in a suitable expression system, which contains a creatinamidinohydrolase gene which contains the deoxyribonucleotide T in position 326 of the natural gene instead of C.
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