| abstract |
The present invention relates to allenic prostacyclin derivatives of the formula:n wherein: n n is 0, 1,2 n R¹ is hydrogen, lower alkyl, lower hydroxyalkyl, or a pharmaceutically acceptable cation; n R² is hydrogen, lower alkyl, cycloalkyl, heteroalkyl, halogen, aryl, alkylthio, phenylthio, alkylsulfinyl, phenylsulfonyl, or trifluoromethyl; n R³ is a lower alkyl, a cycloalkyl, phenyl, benzyl, a cycloheteroalkyl, a lower alkyl having one to eight carbons substituted with one or more fluorines or containing 1 or 2 unsaturated bonds; and carbon 15 may be in the R or the S configuration, or a mixture of R and S with the proviso that when R¹ is a lower alkyl or lower hydroxyalkyl that carbon 15 is not in the R configuration. nThese compounds are useful for the treatment of platelet dysfunction and atherosclerosis. Also disclosed is the process for preparing these compounds and their appropriate intermediates. |