| abstract |
The present invention describes allenic prostacyclin derivatives of the formula:n wherein:n n is 0, 1, 2 R 1 is hydrogen or lower alkyl; R 2 is hydrogen, lower alkyl, cycloalkyl, hetereoalkyl, halogen, aryl, alkylthio, arylthio, alkylsulfinyl, arylsulfinyl or trifluoromethyl; R 3 is a lower alkyl, a cycloalkyl, a cycloheteroalkyl, a lower alkyl having one or more fluorines or containing 1 or 2 unsaturated bonds; ncarbon 15 may be in the R or the S configuration, or a mixture of R and S.n These compounds are useful for the treatment of platelet dysfunction, atherosclerosis, allergic disorders, gastric ulcers, hypertension and tumor cell metastasis. Also disclosed is the process for preparing them and the appropriate intermediates. |