| abstract |
The preparation of recombinant HIV envelope protein gp160, and variants thereof, is accomplished for the first time by use of insect cells and recombinant DNA technology. This progress for preparing intact gp160 is not predictable to any degree from known prior art processes, which process the gp160 to gp120 and gp41. Also disclosed and claimed is the preparation of HIV envelope protein gp120, and HIV variants of gp160. gp160 and gp120 can be used as immunogens to give rise to HIV antibodies. |