| abstract |
Compounds of formula (I):n in which:n Ar represents a phenyl group having at least one substituent selected from nitro, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy and cyano groups and halogen atoms; R represents a C 1 -C 16 alkyl group, a C 3 -C 6 cycloalkyl group, a C 1 -C 4 alkyl group having a C 3 -C 6 cycloalkyl substituent, a C 2 -C 4 alkenyl group, a cinnamyl group or a C 1 -C 16 alkyl group having at least one substituent selected from hydroxy, C 1 -C 4 alkoxy and C 1 -C 4 alkylthio groups; R 1 represents a hydrogen atom or a C 1 -C 3 alkyl group; R 2a and R 2b are the same or different and each represents an unsubstituted phenyl group or a substituted phenyl group having at least one substituent selected from C 1 - C 4 alkyl, C 1 -C 4 alkoxy and C 1 -C 4 haloalkyl groups and halogen atoms; one of R 3 and R 4 represents a methyl group and the other represents an amino group; and n is an integer from 1 to 3; n These compounds have a variety of valuable activities, including antihypertensive and Ca ++- blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted benzylideneacetoacetic acid esters with appropriate amidinoacetic acid esters. |