| abstract |
Compound of formula as well as processes for their preparation, medicaments with calcium-antagonistic properties and the use of these compounds I as medicaments are described.n n n R(1) und R(4) H, Alkyl, Alkoxy, Halogen, CF 3 , N0 2 , OH, Acetamido oder Amino, R(2) H, Alk(en)yl, Phenylalkyl; R(3) H, (Cyclo-)Alk(en)yl, Cycloalkyl-alkyl, Phenyl, Phenylalkyl; A (CH 2 ) 1-4 X-(CH 2 ) 0-3 mit X gleich CH 2 , O, S, CO, CHOH oder CR(5)R(5)'; und R(5) H oder Alkyl; B eine Reihe von (Di)Aminen, T (CH 2 ) 0-3 ; D CHOH, CO, NR(10)CO, CONR(11), 0; E (CH 2 ) 0-3 ; F eine Bindung, NR(12)CO, CONR(13), CO, O; G Phenyl oder Furyl; R(6), R(7), R(8), R(9) H, Alkyl, (Phenyl-)Alkanoyl, Phenylalkyl, Benzhydryl(alkyl), Benzyl; R(10), R(11), R(12) H, Alkyl. The substituents have the following meaning: R (1) and R (4) H, alkyl, alkoxy, halogen, CF 3 , N0 2 , OH, acetamido or amino, R (2) H, alk (en) yl, phenylalkyl; R (3) H, (cyclo) alk (en) yl, cycloalkyl-alkyl, phenyl, phenylalkyl; A (CH 2 ) 1-4 X- (CH 2 ) 0-3 where X is CH 2 , O, S, CO, CHOH or CR (5) R (5) '; and R (5) H or alkyl; B a series of (di) amines, T (CH 2 ) 0-3 ; D CHOH, CO, NR (10) CO, CONR (11), 0; E (CH 2 ) 0-3 ; F is a bond, NR (12) CO, CONR (13), CO, O; G phenyl or furyl; R (6), R (7), R (8), R (9) H, alkyl, (phenyl) alkanoyl, phenylalkyl, benzhydryl (alkyl), benzyl; R (10), R (11), R (12) H, alkyl. |