| abstract |
2-Arytbenzothiazine derivatives represented by general formula (I) and salts thereof, a process for their preparation, and drugs containing them for treating circulatory organ diseases, wherein R' and R 2 may be the same or different and each represents H, lower alkyl, OH, (non)substituted lower alkoxy, acyloxy, -0-THP, halogen, N0 2 , NH 2 , lower alkylamino or (II): R 3 represents H or lower alkyl; R 4 represents H, lower alkyl, cycloalkyl, OH, lower alkoxy, SH, lower alkylthio, arylthio, halogen, CN, formyl lower alkyl, lower alkoxy, lower alkyl or (III); R 5 , R 6 . R 7 , and R 8 may be the same or different and each represents H, (non)substituted lower alkyl, cycloalkyl, acyl, (non)substituted phenyl or (non)substituted pyridyl, or R 5 and R 6 , or R 7 and R 8 , may be bound to each other to form a (non)substrtuted piperidine ring, a (non)substituted piperazine ring or a morpholine ring; Z represents H, lower alkyl, lower alkoxy. OH. halogen, CN, N0 2 , halogenated lower alkyl or lower alkanoyloxy; A represents straight-chain or branched lower alkylene; B represents straight-chain or branched lower alkylene optionally substituted by OH, and n represents O or 1, provided that R 4 and Z do not represent a hvdroaen atom at the same time when n is 0. |