| abstract |
Described is a method for preparing a sustained release formulation utiliing collagen and/or gelatin as a carrier, which comprises the steps:n (i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture consisting of water and a hydrophilic organic solvent under one of the conditions selected from:n (A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration; (B) chemically modified collagen and/or gelatin is employed; and (C) glucose is added to the mixture; (ii) molding the resultant mixture; and (iii) gradually eliminating the solvent from the molded product. |