| abstract |
Derivatives of Penicillin, their sulfoxides and sulfones of the structural formula:n nwhereinn q is 0, 1 or 2; A is, e.g., CH 3 or CH 2 O(CO)CH 3 ; R, is, e.g., R'NR. wherein R. is H or C 1-6 alkyl and R' is, e.g., hydrogen orn nwhere R represents:n (i) hydrogen; (ii) C 1-6 alkyl; (iii) trifluoromethyl or methoxymethyl; (iv) thienyl; (v) phenyl; or (vi) mono- and disubstituted phenyl and thienyl wherein the substituents are selected from the group consisting of chloro, bromo, fluoro, nitro, loweralkyl, and loweralkoxy; n is 0 or 1; B is, e.g., hydrogen or alkyl and R is, e.g., H or halo; nare found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents. |