| abstract |
New substituted cephalosporin sulfones are disclosed having the structural formula:n wherein M is, e.g., trifluoromethyl, chloro or fluoro or-COOH; R 1 is, e.g., hydrogen, hydroxy, mercapto, substituted oxy, substituted thio, hydrocarbyl or substituted hydrocarbyl group; B is OB 1 or NB 2 B 3 wherein B 1 and B 2 independently are, e.g., straight or branched chain alkyl having from 1 to 20 carbon atoms, aryl having from 6 to 10 carbon atoms or cycloalkyl having from 3 to 8 carbon atoms; B 3 is B 1 or hydrogen; and Q is, e.g., hydrogen, C 1-6 alkyl, halo C 1-6 alkyl or hydroxy C 1-6 alkyl. Those compounds are potent elastase inhibitors and thereby useful antiinflammatory/antidegenerative agents. A process for preparing those compounds is also disclosed. |