| abstract |
Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetyiamino group and of the formulan in which R is hydrogen, formyl, a-aminoadipoyl, protected a-aminoadipoyl, or an acyl group of the formulan in which R' is a 5- or 6-membered heterocyclic ring of the for mulaen n n R" is hydrogen, C 1 -C 4 alkyl, a carboxy-substituted alkyl or carboxy-substituted cycloalkyl group of the formula:n n n in which n is 0-3; a and b when taken separately are, independently, hydrogen or C 1 -C 3 alkyl, and when taken together with the carbon to which they are bonded form a C 3 -C 7 carbocyclic ring; R"' is hydrogen, C 1 -C 4 alkoxy, amino, or OR°, in which R° is indanyl, phthalidyl, or an acyloxymethyl group of the formula -CH 2 -O-C(O)-R 2 in wich R 2 is C 1 -C 4 alkyl or phenyl; or COOR° is a protected carboxy group; or R" is an N-substituted carbamoyl group of the formulan in which R"" is C 1 -C 4 alkyl, phenyl or C 1 -C 3 alkyl substituted by phenyl;n Y and m, independently, are integers equal to 0,1,2 or 3, provided that y plus m equals 3; R 1 is hydrogen, C 1 -C 4 alkyl, phenyl, thienyl, amino or C 1 -C 4 alkanoylamino; X is O, S or N-R 2 , where R 2 is hydrogen or C 1 -C 4 alkyl; or a pharmaceutically-acceptable salt or biologically-cleavable ester thereof. |