http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AT-412214-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 |
| filingDate | 1999-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0538539f12fb020e15465bd84e121968 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cf00c26894b7a696441f501a580ecc0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fed0cdf3c64de617bd5fce3e68831bc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e33cabc621e4b9c0db997cc0c0b1297 |
| publicationDate | 2004-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AT-412214-B |
| titleOfInvention | METHOD FOR PRODUCING THE DINATRIUM HEMIHEPTAHYDRATE SALT OF CEFTRIAXONE |
| abstract | Preparation of beta -lactam derivatives (I) comprises: (1) reacting a cephalosporanic acid derivative (IV) with an imine derivative (III) and (2) reacting the obtained compound (II) with a thioether compound (V) to give a compound (VI) which is then desilylated to give (I) or (3) desilylating (II) and reacting with thiourea in a solvent system containing organic solvent and water to give (I). Preparation of beta -lactam derivatives of formula (I) comprises: (1) reacting a cephalosporanic acid derivative of formula (IV) with an imine derivative of formula (III) and (2) reacting the obtained compound of formula (II) with a thioether compound of formula (V) to give a compound (VI) which is then desilylated to give (I) or (3) desilylating (II) and reacting with thiourea in a solvent system containing organic solvent and water to give (I). [Image] [Image] X, R1substituents useful in cephalosporin chemistry; REa negative charge or COOREan ester; R : H or silyl; RE'silyl or COORE'an ester; Y : halo; Y' : a group forming a reactive compound (III); R' : H or silyl and R'' : silyl. An independent claim is included for new compounds of formula (VIa). [Image] R'a>, RE'a, R'''a>tri-1-4C alkylsilyl. ACTIVITY : Antibacterial. No biological data is given. MECHANISM OF ACTION : None given. |
| priorityDate | 1999-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.