http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0091220-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-194 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-194 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 |
| filingDate | 1983-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dea98acb67547caa5137486a108577c |
| publicationDate | 1983-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0091220-A2 |
| titleOfInvention | Thiazole derivatives, process for their preparation and pharmaceutical compositions containing them |
| abstract | N-alkenyl (or N-alkynyl)-N'-[2-(aminoalkyl)-4-thiazolyl- methylthioalkyl]guanidines, thioureas, ethenediamines and related compounds of the following formulan wherein each of R' and R 2 are individually H or (C 1 -C 4 )-alkyl, one of R' and R 2 can be benzyl or benzoyl, and when taken together with the nitrogen to which they are attached, form a saturated heterocyclic ring containing from 5 to 7 ring atoms including 1 or 2 heteroatoms; except that only one of R' and R 2 can be H when Z is CH 2 ;n R 3 is H or (C 1 -C 3 )alkyl; Z is 0, S or CH 2 ; n is 2 or 3 when Z is S or 0 and is 1, 2 or 3 when Z is CH 2 ; m is 1. 2 or 3; R 6 is H or CH 3 ; nwherein A is N-CN, N-NO 2 , CH-NO 2 , S, 0, NH, N-(C 1 -C 4 )alkyl, N-SO 2 -aryl, N-SO 2 -(C 1 -C 4 )alkyl, N-CO-NH 2 , N-CO-(C 1 -C 4 )alkyl, N-C0 2 (C,-C 4 )alkyl, CH-S02-aryl or CH-SO 2 -(C 1 -C 4 )alkyl, wherein aryl is phenyl, halophenyl, (C 1 -C 4 )alkylphenyl or (C 1 -C 4 )alkyloxy- phenyl; and R is (C 2 -C 4 )alkenyl or (C 2 -C 4 )alkynyl; and R 8 and R 9 are individually H, CH 3 or C 2 H 5 , with the proviso that the total number of carbon atoms in the group CR 8 R 9 R be less than 7; or a pharmaceutically-acceptable salt thereof. The compounds are H 2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9110657-A1 |
| priorityDate | 1982-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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