| abstract |
Thiazole derivatives of the formula:n wherein each of R' and R independently represent hydrogen, C 1-4 alkyl, benzyl or benzoyl, or, taken together with the adjacent nitrogen atom, form a saturated heterocyclic ring containing from 5 to 7 ring atoms,n R 3 is hydrogen or C 1-4 alkyl, Z is 0, S, or CH 2 , n is 2 or 3 when Z is 0 or S and n is 1, 2 or 3 when Z is CH 2 , R 5 is hydrogen or C 1-4 alkyl, m is 1, 2 or 3,n wherein A is N-CN, N-NO2, CH-NO 2 , S, 0, NH, N-SO 2 - aryl, N-SO 2 -C 1-4 alkyl, N-CO-NH 2 , N-CO-C 1-4 alkyl, N-CO 2 -C 1-4 alkyl; CH-SO 2 -aryl or CH-SO 2 -C 1-4 alkyl, wherein aryl is phenyl, halophenyl, C 1-4 alkylphenyl or C 1-4 alkoxyphenyl, and B is NRR 6 , wherein R and R 6 are independently hydrogen, C 1-5 alkyl, C 3-6 cycloalkylmethyl, hydroxy C 2 - 5 alkyl, C 3 . 6 cycloalkyl, alkoxyalkyl or dialkyl-aminoalkyl wherein the total number of carbons is less than 8 and there is at least a two-carbon chain between the hetero atoms, or YR 4 , wherein Y is oxygen or sulfur and R 4 is C 1-5 alkyl, -CH 2 C 2-4 alkenyl or benzyl, or a pharmaceutically acceptable salt of a compound in which B is NRR 6 , have been found to possess activity as H 2 antagonists and are therefore of value as antiulcer agents. |