| abstract |
In addition to thrombin, a dry preparation with a foam or fleece structure obtained by freeze-drying essentially consists of at least catalytically effective amounts of approximately 10 to 95% by weight of fibrin and approximately 5 to 90% by weight of fibrinogen. For the production, fibrin is generated in situ in an aqueous solution containing fibrinogen and thrombin, and the resulting reaction mixture is deep-frozen and lyophilized. Active ingredients such as antibiotics, natural bone material and / or synthetic, bone-forming substitute, glycoproteins, coagulation-promoting substances and the like, and / or fibrinolysis inhibitors come into consideration as further components of the dry preparation. The dry preparation is primarily intended as a wound care material, filling material for bone cavities and / or as a carrier material for other active substances. |