abstract |
The present invention relates to a method for producing conjugates of the active substance and hydroxyalkyl starch and to conjugates of the active substance and hydroxyalkyl starch, preferably hydroxyethyl starch, where the conjugates are prepared by covalently linking hydroxyalkyl starch and the active substance using a chemical residue having the structure of formula (I) ((I ') I ″), in which R, R, R, R, R and R are independently selected from the group consisting of hydrogen, optionally suitably substituted, linear, cyclic and / or branched an alkyl, aryl, heteroaryl, aralkyl and heteroaralkyl group, preferably hydrogen. |