| abstract |
Compounds of the formula <IMAGE> in which R<1> represents unsubstituted or substituted lower alkyl, lower alkenyl, lower alkynyl, mono-, bi-or tricycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl, aryl-lower alkenyl, heteroaryl or heteroaryl-lower alkyl, and also unsubstituted or substituted hydroxyl or amino, R<2> represents hydrogen, unsubstituted or substituted mono-, bi- or tricycloalkyl, aryl or heteroaryl, R<3> represents unsubstituted or substituted hydroxyl or amino, His represents the divalent radical of the natural amino acid L-histidine, Z represents substituted carbonyl, thiocarbonyl or iminocarbonyl, unsubstituted or substituted phosphono, aminomethyl, thiomethyl, sulphinylmethyl, sulphonylmethyl, or phosphonomethyl, m, n or p represents 0, 1 or 2 and q represents 0, 1, 2, 3 or 4, and salts of such compounds with salt-forming groups inhibit the hypertensive action of the enzyme renin and can be used as antihypertensives. |