| abstract |
Oxadiazoles of formula (I): are prepd. by reacting acylamidine salts (II) first with a hypohalite (III) MOX and secondly with a NH4 or alkali(ne earth) cpd. in presence of a solvent. In the formulae R1 and R2 are each H, aliphatic, cycloaliphatic araliphatic, aromatic or heterocyclic gps. or R3NH; R3= aliphatic or aromatic gp. and R2 may also be (R3)2N or R3O; X is halo and M is a cation esp. Na or K. (I) are inters. for dyes, pesticides, optical brighteners and pharmaceuticals, Some have insecticidal, fungicidal, herbicidal, antibacterial, anti-inflammatory, sedative, convulsive and coronary-dilating activity. |