| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec5b8c0fc1f827c1360a8f5ea5652225 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate |
1999-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78eb62b89f2cce23de1573667a63a815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28113a39268c9c28609323e8312aeb55 |
| publicationDate |
2000-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-19907567-A1 |
| titleOfInvention |
Process for the microbial production of L-valine |
| abstract |
The present invention relates to a method for the microbial production of L-valine, in which the dihydroxy acid synthase (ilvD) activity and / or the ilvD gene expression is increased in a microorganism. Alternatively or in combination with this, the acetohydroxy acid synthase (ilvBN) and isomeroreductase (ilvC) activity and / or the ilvBNC gene expression in a microorganism is increased. Microorganisms in which the activity of at least one enzyme which is involved in a metabolic pathway which reduces L-valine formation, is weakened or switched off are preferably used for the processes according to the invention. Thus, microorganisms with a defect mutation in the threonine dehydratase (ilvA) gene and / or with a defect mutation in one or more genes of pantothenate synthesis are preferably used in the methods according to the invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02057476-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1860193-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02057476-A2 |
| priorityDate |
1999-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |