http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102014208876-B4

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filingDate 2014-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-102014208876-B4
titleOfInvention Process for the preparation of carotenoids by submerged fermentation with mixed cultures of (+) and (-) strains of the fungus Blakeslea trispora
abstract A process for the preparation of a carotenoid selected from β-carotene or lycopene by submerged fermentation with mixed cultures of (+) and (-) - strains of the fungus Blakeslea trispora and recovery of the carotenoid from the obtained biomass, characterized in that first the (-) - and the (+) strain is pre-cultured separately until fully morphologic, then the (-) strain is inoculated into the bioreactor, and during the exponential growth of the (-) strain, the (+) strain is inoculated into the (-) strain in the volume ratio 1: 5 to 1: 100 is added to induce the carotenoid formation and both strains are fermented together without pH regulation and without regulation of the oxygen partial pressure at 18 to 24 ° C until the end of carotenoid formation.
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