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filingDate 2015-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb6ac55f587cd692c887053d7645facd
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publicationDate 2017-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-306479-B6
titleOfInvention A method for crosslinking polysaccharides using photolabile protecting groups
abstract The present invention relates to a process for preparing cross-linked polysaccharide-based materials by electromagnetic radiation in an aqueous solution containing a carbamate photolabile protecting group polysaccharide (FCS with an -NH-CO-O- group) and an aldehydic group -CHO polysaccharide. The cross-linking process itself is performed by the condensation reaction of the photolytically released amino group (-NH 2 -) with the aldehyde group (-CHO) to form an imine-type moiety (-N = CH-). Both processes take place simultaneously and can be realized under physiologically acceptable conditions. The advantage of the proposed solution is the time and spatial control of the cross-linking process allowing the preparation of advanced tissue engineering materials with the possibility to control the degree of cross-linking and thus the mechanical properties in the material structure.
priorityDate 2015-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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