| abstract |
Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologically, in inhibiting certain thiol-containing enzymes such as H<+>/K<+>-ATPase (the proton pump), and industrially, in selective removal of thiol compounds from gas or liquid mixtures. |