http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112457272-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-08 |
| filingDate | 2020-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112457272-B |
| titleOfInvention | Preparation method of (3-methoxy-1, 2, 4-thiadiazole-5-amino) phenyl formate |
| abstract | The invention discloses a preparation method of (3-methoxy-1, 2, 4-thiadiazole-5-amino) phenyl formate, belonging to the field of synthesis of medical intermediates. Starting from O-methylisourea hydrochloride (1), carrying out chlorination reaction to obtain an intermediate (2); and then the intermediate (2) and thiocyanate are subjected to ring closure under the presence of ytterbium catalyst to obtain an intermediate (3), and finally the intermediate (3) and phenolate react in the presence of CDI to obtain (3-methoxy-1, 2, 4-thiadiazole-5-amino) phenyl formate. The method has the advantages of simple and stable operation, easy separation of products in each step, high yield and environmental protection, and provides a new synthetic approach for the compounds. |
| priorityDate | 2020-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.