http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114685572-B

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04
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filingDate 2022-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114685572-B
titleOfInvention Oxidant composition for synthesizing MGB nucleic acid probe and method for synthesizing the probe
abstract The present invention provides an oxidant composition for synthesizing MGB nucleic acid probes, the composition comprises: oxidant iodine, and a compound that competes with N-H bond on MGB to bind oxidant iodine and does not interfere with MGB, the compound has a specific The N-H bond on the MGB has a stronger ability to bind with the oxidant iodine. The MGB probe prepared by the method of the invention improves the performance, uniformity and stability of the probe in the QPCR experiment, especially reduces the fluorescence background in the PCR reaction, improves the fluorescence signal of the reaction, and significantly increases the detection confidence. noise ratio.
priorityDate 2022-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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