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filingDate 2021-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec46d1970f1122366e09f239bccf2878
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publicationDate 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114354802-A
titleOfInvention Analytical method for the content of two cyanobenzyl bromide isomers in alogliptin benzoate
abstract The invention relates to the technical field of analysis and detection, in particular to a method for analyzing the content of two cyanobenzyl bromide isomers in alogliptin benzoate. The analytical method utilizes a triple quadruple-mass spectrometer to measure the contents of 3-cyanobenzyl bromide and 4-cyanobenzyl bromide in alogliptin benzoate at one time, using direct sample injection, and the chromatographic column adopts VF-624MS Capillary column, mass spectrometry adopts MRM mode, and the content of 3-cyanobenzyl bromide and 4-cyanobenzyl bromide is analyzed by standard curve method. The analysis method of the invention overcomes the difficulties that the two cyanobenzyl bromide isomers are similar in properties and difficult to separate, and the detection time is saved, and the detection method is efficient and accurate.
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