http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109580835-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_469a706d1b8daec98551a0d173f526f8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-60 |
| filingDate | 2018-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_883ad91bb399934eed78a0f5e5020c5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4b868ec22feb1a5f6c223a1d88fa99e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99b93a4911ee3f3c27bec85cdd97f37c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b425875eb6f8f6e5ca57b0b7ad3aae2b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdd45abbdd72f97f37f9be0812c7ae8a |
| publicationDate | 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109580835-A |
| titleOfInvention | A kind of method for separating and determining alogliptin related substances by liquid chromatography |
| abstract | The invention relates to a method for separating and determining alogliptin related substances by liquid chromatography. The specific steps of the method are as follows: take 0.528 g of ammonium sulfate, add 1000 ml of water to dissolve, and adjust the pH value to 3.0 with glacial acetic acid to obtain an ammonium sulfate buffer solution, namely mobile phase B; press (35-37.5) ammonium sulfate buffer solution and methanol : (62.5-65) ratio to obtain mobile phase A; adopt C30 column, carry out gradient elution with mobile phase A and mobile phase B, the detection wavelength is 250-280nm, the column temperature is 25-40 ℃, and the flow rate is 0.5- 3ml/min, the injection volume is 5-50uL. Compared with the prior art, the method of the present invention has the advantages of simple operation, good stability, high sensitivity and strong specificity, and adopts C30 column for separation, so that the separation degree between the related substances of alogliptin is good, Can reduce mobile phase salt consumption. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114354802-A |
| priorityDate | 2018-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.