| abstract |
The invention provides a mixed gel for injection and a preparation method and application thereof. The mixed gel for injection comprises a gel matrix and polyhydroxyalkanoate microspheres, and the molecular weight of the polyhydroxyalkanoate microspheres is 50,000. ~500,000 Daltons, the average particle size is 30-50 microns, and the mass fraction in the mixed gel is 15-30%. By mixing PHA microspheres with a specific molecular weight and an average particle size with a gel matrix, the formed mixed gel has a good filling effect, can maintain mechanical properties during the degradation process, and can stimulate collagen proliferation after being injected into the dermis of the skin. , activates the skin, effectively and gradually smoothes wrinkles, realizes the remodeling of the skin contour, and achieves the effect of long-term filling. In addition, its degradation product 3-hydroxybutyric acid is a natural source of energy for human cells, which can promote the growth of fibroblasts and collagen. Regenerate and make the cosmetic filling effect more pronounced. |