| abstract |
The invention discloses a nano-medicine with an oxidative phosphorylation inhibitor loaded on a heteromembrane and a preparation method thereof, and relates to the technical field of medicine carriers. It includes an inner core and an outer shell, the outer shell is wrapped around the inner core, the inner core includes ROS-responsive drug-loaded nanoparticles, the drug contained in the ROS-responsive drug-loaded nanoparticles is an oxidative phosphorylation inhibitor, and the outer shell is a mixture of mitochondrial membrane and tumor cell membrane. membrane. The nanomedicine can cross the BBB and reach the tumor site with the help of the homologous targeting of the tumor cell membrane, and can be homologously targeted and entered into the mitochondria with the help of the mitochondrial membrane. The ROS-responsive drug-loaded nanoparticles can reduce the swelling of the inner core under the environment of high mitochondrial ROS. Explain and release the loaded substance oxidative phosphorylation inhibitor, so as to realize safe and efficient targeted drug therapy. Through the encapsulation of the shell, the defect of the short half-life of the loaded drug in the blood is avoided, and the long circulation of the drug in the blood is greatly protected. |