| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4e962df11450f7fb96181ddd2d08f1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d94573ab2c57e8b193f3a22accddf9fe |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-45 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate |
2021-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45d8ce00d665f6ad3c95771bdb6e738e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db8ae8111e975acc62f67fc77dfbfc9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_506f637a3b4b16454ed06964945e6ae8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_960a2d029ff08b82c510b4d67a304006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1e9db3a0a36f139a8d1ae842f0ba683
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85b27b9bc414b08a7b6ca0a696bd7534
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32ba679ddd36e48309a3d4edf4fc4c23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae977f3a959b8ed771e84c91a6de3af1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62fedad4971bd9232ffaf14b162c8466 |
| publicationDate |
2021-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-113278624-A |
| titleOfInvention |
Synthesis of modified Olig2 mRNA and its application |
| abstract |
The invention relates to a synthetically modified Olig2 mRNA and its application, and belongs to the technical field of stem cell induction and differentiation. The protein translated by this Olig2 mRNA is always in a dephosphorylated state. It was transfected into neural precursor cells derived from human induced pluripotent stem cells to achieve rapid and efficient directed differentiation of human induced pluripotent stem cells into oligodendrocytes, and the designed modified Olig2 mRNA showed higher efficiency than wild type. High differentiation-inducing ability. The method of the present invention can realize the rapid differentiation of induced pluripotent stem cells into oligodendrocytes, and can avoid the risk of gene integration in the oligodendrocytes induced by the overexpression of transcription factor SOX10 in the past, which is more beneficial to clinical practice The development of the test. The oligodendrocytes derived from human induced pluripotent stem cells of the present invention are rapidly induced, and provide technical support for the treatment of myelin damage-like neurodegenerative diseases by transplantation of oligodendrocyte precursor cells in the future. |
| priorityDate |
2021-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |