| abstract |
The invention discloses pyrrole BET inhibitors and a preparation method and application thereof. The compound has the structure shown in general formula (I) or one or more mixtures of tautomers, mesomers, racemates, enantiomers, diastereomers thereof, or pharmaceutically acceptable salts thereof. Such compounds or their mixtures or their pharmaceutically acceptable salts use ethyl acetoacetate derivatives and aminoaryl ethyl ketones as starting materials, and obtain the compound of general formula (I) through continuous reaction, and the preparation method thereof is relatively simple and convenient. The preparation method is easy to obtain and has good applicability, and the medicament with the derivative as the active ingredient can be effectively used in the medicament for preventing and/or treating diseases related to BET protein. |