http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113248445-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-32 |
| filingDate | 2021-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113248445-B |
| titleOfInvention | A kind of synthetic method of fenbendazole |
| abstract | A method for synthesizing fenbendazole belongs to the technical field of repellents, and the specific steps are: using 5-chloro-2-nitroaniline and sodium thiophenate aqueous solution to undergo condensation reaction in a mixed solution of n-propanol and water 5-phenylthio-2-nitroaniline is obtained; 5-phenylthio-2-nitroaniline is catalyzed by Raney nickel to generate 4-phenylthio-o-phenylenediamine by reduction reaction in the autoclave; 4-benzene Sulfo-o-phenylenediamine and N-(trichloromethyl) methyl carbamate are mixed to obtain fenbendazole through cyclization reaction; the advantages of the synthetic method are: mild conditions, easy to operate, can avoid the cyclization process The generation of ammonium chloride, the cost of the three wastes is low; the generation of amine salts is avoided, and the cost of the three wastes treatment is greatly reduced; the yield of fenbendazole can reach 84.27-89.99%, and the purity of fenbendazole can reach 96.39-99.71 %. |
| priorityDate | 2021-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.