http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109467535-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_506ad7baea5fd83a641046e2210f88fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-32 |
| filingDate | 2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0f327ca4cbded0def7249ab60a64f07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae1f6fadfb28448dda1f32a37437ee21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4f68713448f85a4d86eb55fa273b463 |
| publicationDate | 2019-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109467535-A |
| titleOfInvention | A kind of preparation method of fenbendazole |
| abstract | The invention discloses a preparation method of fenbendazole. It is characterized in that: (1) using m-dibromobenzene as a starting material, through nitric acid/sulfuric acid system nitration reaction, to prepare intermediate 1 (2,4-dibromonitrobenzene); (2) using intermediate 1 as a raw material , through the ammoniation reaction that ammonia methanol solution participates in, prepares intermediate 2 (5-bromo-2-nitroaniline); (3) takes intermediate 2 and sodium thiophenolate solution as raw materials, through condensation reaction, prepares Intermediate 3 (4-phenylthio-2-nitroaniline); (4) Intermediate 3 is subjected to palladium-carbon catalytic hydrogenation reduction to generate intermediate 4 (4-phenylthio-1,2-phenylenediamine) ; (5) Intermediate 4 and methyl cyanamide formate aqueous solution, through cyclization reaction, generate product fenbendazole. The method is clean and environmentally friendly, with low production cost, product purity of more than 99.5%, and yield of not less than 84.0%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111349032-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111349032-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113185436-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110683966-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111499549-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113248445-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111499549-B |
| priorityDate | 2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.