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filingDate 2021-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_578f1bed1307f42292b2d2c4baeebc4a
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publicationDate 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113189060-A
titleOfInvention Fluorescent sensor for detecting breath ammonia and preparation method and application thereof
abstract The invention provides a fluorescence sensor for detecting respiratory ammonia, which is compounded by curcumin derivative (BFCUR) with large steric hindrance and Electrospun Nanofiber (ENF) with high porosity and high specific surface area. The BFCUR with large steric hindrance is used as a sensing fluorophore, so that aggregation caused by pi-pi accumulation is effectively avoided; whereas ENF with high porosity and high specific surface area can improve the sensitivity of the sensor. The sensor disclosed by the invention has excellent performance in respiratory ammonia detection, has an ultralow detection limit, a wider ammonia concentration response range and quick response time, is less interfered by carbon dioxide and water vapor, and has high cycle stability, high light stability and good recoverability. The sensor of the invention has been successfully applied to the detection of the respiratory ammonia of patients with chronic kidney diseases and helicobacter pylori infection, has high sensitivity and reliable detection result, and has important significance in clinical practice.
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