http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113046391-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca82d85ba526a9d85bc53f9c7a5be440 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2021-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31c25e31f31662ab1d3207e89e3d4f02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_785f784357e4840c14d0e789d3b2cc5c |
| publicationDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113046391-A |
| titleOfInvention | Construction method and application of a CRBN gene humanized animal tumor cell model |
| abstract | The invention relates to the technical field of animal genetic engineering and genetic modification, in particular to a construction method and application of a CRBN gene humanized animal tumor cell model. A method for constructing a CRBN gene humanized animal tumor cell model, comprising: introducing tumor cells into a humanized mouse, wherein the CRBN gene of the humanized mouse includes I391V mutation. The CRBN gene humanized animal tumor cell model constructed in the present invention can not only be used for the evaluation of the efficacy of immunomodulatory drugs, but also has important guiding significance for the clinical effects of drug development. At the same time, it is also an ideal mouse tumor cell model for the safety evaluation of IMiDs drugs. |
| priorityDate | 2021-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.