| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9bad9b23c98772b92fc5921751f918e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f312cc7676e939dee48fb4fdfe921ce8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2019-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fa760ab35d8f32d32bd12c4bc623b3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27436843580ca9dde7b86a92eb9c9dc1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a978f7b247f5b624ec4f6a83d1460224 |
| publicationDate |
2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110934107-A |
| titleOfInvention |
A kind of construction of humanized mouse tumor model and preparation method and application thereof |
| abstract |
The present invention provides a humanized mouse tumor model, characterized in that, the humanized mouse tumor model is obtained by transplanting human thymus tissue and CD34+ hematopoietic stem cells homologous to the thymus tissue. The present invention constructs a humanized mouse tumor model transplanted by thymus and hematopoietic stem cells for the first time. The humanized mouse tumor model has been determined to have a complete immunosuppressive microenvironment, and is suitable for the overall evaluation of solid tumor immunotherapy, and can be used to evaluate the feasibility and effectiveness of immunotherapy efficacy. The invention makes up for the singleness and incompleteness of the existing tumor immunotherapy evaluation methods, provides reference value for clinical research, and complements the key role of the human immune system in immunotherapy compared with traditional models. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112931410-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113046391-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113999876-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113999876-B |
| priorityDate |
2019-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |