http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112980859-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2019-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112980859-B |
| titleOfInvention | Methods for reducing the stability of the LKB1-STRAD-Mo25 protein complex |
| abstract | The invention discloses a method for reducing the stability of LKB1-STRAD-Mo25 protein complex. Elevating the expression level of Midkine protein in human or mammalian cells can inhibit the stability of the LKB1‑STRAD‑Mo25 protein complex. The Co-Immunoprecipitation (Co-IP) experiment was performed on LKB1 as a bait protein, and the levels of STRAD and Mo25 proteins bound by LKB1 were detected by Western blot, which could verify the stability of Midkine protein to LKB1-STRAD-Mo25 protein complex negative regulation. The establishment of the present invention provides a method for reducing the stability of the LKB1-STRAD-Mo25 protein complex, provides help for studying the biological function of the LKB1 protein, and provides a new theoretical basis for using LKB1 as a target in tumors and diabetes. |
| priorityDate | 2019-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.