| abstract |
The invention provides a beta-ketone sulfoxide derivative of carboxylic acid drugs, a preparation method and application thereof, belonging to the technical field of organic synthesisA domain. Using acyl chloride derivatives of carboxylic acids as raw materials in CaC 2 Preparation of beta-ketosulfoxide derivatives of this class of drugs in the Presence of TEA, in one aspect, in CaC 2 Under the coexistence of TEA, the yield of the prepared beta-keto sulfoxide derivative is up to 49-64%, and the beta-keto sulfoxide derivative is green and environment-friendly, mild in reaction process and simple to operate. On the other hand, the prepared beta-keto sulfoxide derivative is used as a medicament for treating respective indications, has less stimulation to intestines and stomach after entering a human body, and has the advantages of high activity, low toxicity and high added value. |