http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112812033-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653c418e41edbb4e1ce8bc5e53e70cec |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2021-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41ba2f8ae585b3e1cc1d81a370206606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a77639db6fbfea55ea25e225633b2a1 |
| publicationDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112812033-A |
| titleOfInvention | A kind of new synthesis method of oseltamivir |
| abstract | The invention provides a new synthesis method of oseltamivir. The method uses compound (E)-2-(2-nitrovinyl) isoindoline-1,3-dione and ethyl pyruvate as The starting material, under the catalysis of thiourea catalyst, undergoes a Michael addition reaction to obtain the corresponding Michael addition product; then the Michael addition product and (formylmethylene) triphenylphosphine generate a one-pot Wittig The reaction is reacted with Henry to obtain a ring-closed product; then the ring-closed product and trichloroacetonitrile intermediate form an etherified product, which is reduced, acetylated and deprotected to obtain oseltamivir. The reaction route of the present invention has six steps, and the raw materials used in each step of the reaction are readily available and inexpensive, the operation is simple, and the reaction yield of each step is high, and no heavy metals and azide compounds are used in the entire synthesis process. , is green and safe, and can be used in industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114539088-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114539088-A |
| priorityDate | 2021-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.