| abstract |
The present invention provides a method for preparing oseltamivir phosphate preparations capable of preparing highly safe oseltamivir phosphate preparations as pharmaceuticals with high yield, suitable for large-scale synthesis, and an intermediate compound of oseltamivir phosphate. In the preparation method of the present invention, by utilizing the Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, an intermediate compound represented by the following general formula (V) is synthesized, and the intermediate compound is changed Substituent, and then prepare oseltamivir phosphate. |