| abstract |
The invention discloses a method for determining high molecular weight in cefuroxime axetil raw materials, which comprises the following steps: chromatographic conditions include a high-efficiency gel chromatographic column, a detector is UV, and a mobile phase is 0.03 mol/L lithium halide at 25- 35% N,N-dimethylformamide solution containing unit alcohols with 3 to 8 carbon atoms. The method of the invention has better solution stability, can effectively prevent the degradation of the cefuroxime axetil to be tested, and ensure the stability of the sample, so that the macromolecular polymer in the cefuroxime axetil raw material can be controlled more accurately, and the product can be guaranteed. quality, prevent allergic reactions caused by polymers, and better ensure safe medication for patients. |