| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b75a05785dbfd86d27a87ddcdc5a524 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 |
| filingDate |
2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_809fa2ccbf8ec813a498014d8708186a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e694999f36b972b465442127a18a7d25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07d4403737621c56165b9114c8fe24c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cf4884deef4810005a055763c0385f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1571f9399219463a4ec2c1b5be896daa |
| publicationDate |
2020-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111956663-A |
| titleOfInvention |
Preparation method and application of realgar nanoparticles |
| abstract |
The invention provides a preparation method and application of realgar nanoparticles, and the realgar nanoparticles mainly include As 4 S 4 , BSA and FA. The preparation method comprises the following steps: using As 4 S 4 ethylenediamine molecular cluster solution as a precursor, and utilizing acid-base reaction to make As 4 S 4 nucleate and grow under the stability of BSA to form nanoparticles. The realgar nanoparticles can be further modified with targeting ligands to increase the targeting and therapeutic index of tumor cells. The realgar nanoparticles of the present invention can down-regulate the level of BCR-ABL protein, induce apoptosis of chronic myeloid leukemia cells from the mitochondrial pathway, and reduce potential toxic and side effects. |
| priorityDate |
2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |