| abstract |
The invention relates to a preparation method of tert-butyl-8-oxyidene-2-azaspiro[4.5]decane-2-carboxylate, mainly solves the high cost of raw materials and difficult reaction control in the existing synthesis process, Technical problems such as inconvenient experimental operation, the present invention uses cheap and easily available 1,4-dioxaspiro[4.5]decane-8-ketone as starting material, and prepares tert-butyl-8-oxygenidene through four-step reaction -2-Azaspiro[4.5]decane-2-carboxylate. The reaction formula is as follows: , the tert-butyl-8-oxygenidene-2-azaspiro[4.5]decane-2-carboxylate obtained by the present invention is a useful intermediate or product for the synthesis of many medicines. |