| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9254bb14ca1302181a47fb4d4f96127f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0667
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0668
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0663 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775 |
| filingDate |
2020-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f959d635a298aaa571053c1349857460
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c1ca1d37f2639b5e61bfca7b69d8e57 |
| publicationDate |
2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111471647-A |
| titleOfInvention |
Preparation method of adult stem cell exosome and its application in the treatment of Parkinson's disease |
| abstract |
The invention discloses a preparation method of adult stem cell exosome and its application in the treatment of Parkinson's disease, and belongs to the field of biomedical technology. Bone marrow mesenchymal stem cells, skin epidermis-derived stem cells and adipose-derived stem cells are isolated and cultured in vitro, and exosomes in the cell culture supernatant are extracted by ultracentrifugation, and administered by nasal administration. The exosomes from the three sources can significantly alleviate the related symptoms of Parkinson's model mice, such as restoring the motor function of the mice and increasing the number of dopaminergic neurons in the substantia nigra of the mouse brain. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113143968-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113069532-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114848674-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113040877-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113143968-B |
| priorityDate |
2020-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |