http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111454258-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0258 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-643 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2409 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 |
| filingDate | 2020-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111454258-B |
| titleOfInvention | Preparation method of solifenacin intermediate |
| abstract | The invention relates to a preparation method of a solifenacin intermediate. The preparation method comprises the following steps: dissolving 3-quinuclidinone hydrochloride to obtain 3-quinuclidinone hydrochloride solution; adding an alkaline compound and a catalyst into the 3-quinuclidinone hydrochloride solution, introducing hydrogen, and stirring for reaction to obtain a reactant; filtering and recovering the catalyst in the reactant, and recrystallizing the obtained filtrate after decompression and concentration; the catalyst has a structure shown in a formula I; the polymerization degree of the PEG is 60-400. In the preparation method, the catalyst is easy to separate, the risk of heavy metal residue is reduced, the reaction operation is simple, convenient and safe, the three-waste treatment is simple and easy to implement, and the method is environment-friendly, is a green synthesis process, has high and stable yield and low production cost, and is suitable for industrial production. |
| priorityDate | 2020-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.