| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca69639f4e98af6919f6826db34a6573 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-78 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate |
2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce2381c835c0d6578e0bcc746eddf8b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e40911185ffca056bf94ee091a3bd500
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f7d29a6d46638dbcffedf43a50b4232
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e4c9f98371d3aaf3fde3646911a6a02 |
| publicationDate |
2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111440142-A |
| titleOfInvention |
Preparation method of morpholinoquinazoline compound and intermediate thereof |
| abstract |
The invention discloses a preparation method and an intermediate of a morpholinoquinazoline compound. The preparation method of the morpholinoquinazoline compound provided by the present invention comprises the following steps: Step S1: subjecting compound S and compound IV to the Suzuki reaction of the following formula to obtain compound V; step S2: combining methylsulfonyl chloride and The compound V is subjected to the following formula reaction in an organic solvent to obtain compound VI; Step S3: compound VII and the compound VI are subjected to a coupling reaction of the following formula in a solvent to obtain compound YY-20394. The preparation method of the invention has high yield, good selectivity, simple operation, mild reaction conditions, and is suitable for industrial production. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114478465-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022199375-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115252620-A |
| priorityDate |
2019-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |