http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111388761-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-28 |
| filingDate | 2020-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111388761-B |
| titleOfInvention | Application of gastrodin in medical titanium metal use in diabetes environment |
| abstract | The application of gastrodin in the medical titanium metal implant in the diabetes environment. After the medical material is implanted into a human body, the tissue repair of a 'material-bone' interface mainly relates to the integration of new bone tissues and materials, wherein the biological activity and the function of osteoblasts responsible for osteogenic differentiation on the materials determine the osseointegration effect of the materials. The invention establishes an in vitro 'titanium-bone' interface model by carrying out osteoblast adhesion culture on the surface of medical titanium metal, and uses gastrodin with therapeutic dose for addition culture, thereby proving the improvement effect of the gastrodin on the biological function of the 'titanium-bone' interface osteoblasts in a diabetic environment. The invention solves the clinical problems that the diabetes environment causes oxidative stress damage to the osteoblasts at the titanium-bone interface, influences the biological function of cells and aggravates apoptosis damage, and finally leads to poor osseointegration and long-term loosening of the titanium metal implant in the prior art, so as to improve the stability of the medical titanium metal implant. |
| priorityDate | 2020-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 189.