| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ccdcff57ee47be00e2cdddc874b8785d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088 |
| filingDate |
2020-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_876d31ecedbdddc00a5f4c8e7145cb7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40b43c583cd2c07ab179113093cac9a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a1531ebf9f7f2a004db8b44ca0e918d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ded51ebdd9579d4eef55d1361a8fec19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1011f01ea8288b8db1dec0aa94914883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b088a9a711def614c5fcc1b61d220d47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15ff07777a63bc94925f31162c6baa1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e62c0bd12c26a628fe8146a0c98b2d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_664797e6975d385e42adc4d322aed62f |
| publicationDate |
2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111349057-A |
| titleOfInvention |
Synthesis and preparation method of a new type of curcumin derivatives and application in tumor therapy |
| abstract |
The invention provides the structure, preparation method and application prospect of a novel curcumin derivative in the field of tumor treatment. Computer molecular simulations show that: the curcumin derivatives provided by the present invention have significant interactions with the SH2 domain of STAT3, a key protein in the human cell signaling pathway; in addition, the results of the cell proliferation experiment (CCK-8) show that the present invention The compounds involved have obvious proliferation inhibitory effects on both parent and EGFR inhibitor-resistant (human) non-small cell lung cancer cell lines PC9 and HCC827, and their biological activities are better than curcumin. This research will be of great significance to the application of such compounds in the clinical treatment of tumors and other biological aspects. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115160257-A |
| priorityDate |
2020-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |